Replicating Programs in Social Markets

This paper details the multiple factors that must be taken into account in assessing a programs chances of being successfully replicated, and investigates the various dimensions of replicability -- the program, the process, and the market. The dimensions of replicability represent a systematic method for parsing the opportunity that arises when a program model appears ready for broader implementation

Capturing the Essential Elements

When a program with demonstrated effectiveness is expanded, knowing how it works and why it works the way it does is an indispensable first step in preserving its quality. This report draws on P/PV's experience with different programs to show how to define a model's essential elements to increase the chances of successful replication. It contains lessons for program developers, funders and practitioners interested in adopting model programs

Investing in What Works

Getting organized for replication is no simple matter. There are many moving parts to a replication effort, and each needs to be thought through carefully. This working paper details the questions that should frame any serious replication effort

Dissolving Dualities

This article provides an experience-based challenge to some of the most common myths about replication: programs can never be replicated, only adapted to unique local circumstances; competition has no place in the social sector; and it takes charismatic leadership to take a program to scale

Rock 'n' Roll Solutions to the Hubble Tension

Local measurements of the Hubble parameter are increasingly in tension with the value inferred from a $\Lambda$CDM fit to the cosmic microwave background (CMB) data. In this paper, we construct scenarios in which evolving scalar fields significantly ease this tension by adding energy to the Universe around recombination in a narrow redshift window. We identify solutions of $V \propto \phi^{2 n}$ with simple asymptotic behavior, both oscillatory (rocking) and rolling. These are the first solutions of this kind in which the field evolution and fluctuations are consistently implemented using the equations of motion. Our findings differ qualitatively from those of the existing literature, which rely upon a coarse-grained fluid description. Combining CMB data with low-redshift measurements, the best fit model has $n=2$ and increases the allowed value of $H_0$ from 69.2 km/s/Mpc in $\Lambda$CDM to 72.3 km/s/Mpc at $2\sigma$. Future measurements of the late-time amplitude of matter fluctuations and of the reionization history could help distinguish these models from competing solutions.Comment: 19 pages, 9 figures + appendi

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events

International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae. Using a combination of in vitro and in vivo methods, we show that, similar to mammalian eIF4G, yeast eIF4G homologues, Tif4631p and Tif4632p, are present both in the nucleus and the cytoplasm. We show that both eIF4G proteins interact efficiently in vitro with UsnRNP components of the splicing machinery. More specifically, Tif4631p and Tif4632p interact efficiently with U1 snRNA in vitro. In addition, Tif4631p and Tif4632p associate with protein components of the splicing machinery, namely Snu71p and Prp11p. To further delineate these interactions, we map the regions of Tif4631p and Tif4632p that are important for the interaction with Prp11p and Snu71p and we show that addition of these regions to splicing reactions in vitro has a dominant inhibitory effect. The observed interactions implicate eIF4G in aspects of pre-mRNA processing. In support of this hypothesis, deletion of one of the eIF4G isoforms results in accumulation of un-spliced precursors for a number of endogenous genes, in vivo. In conclusion these observations are suggestive of the involvement of yeast eIF4G in pre-mRNA metabolism

The Essential Connection: Using Evaluation to Identify Programs Worth Replicating

This publication describes how to use practical evaluation methods to identify social programs that are both effective and capable of being successfully transferred to new settings. It also provides guidance in making sound decisions about the suitability of investing time and money in program expansion

The two-mode puzzle: Confronting self-interacting neutrinos with the full shape of the galaxy power spectrum

A cosmological scenario in which the onset of neutrino free-streaming in the early universe is delayed until close to the epoch of matter-radiation equality has been shown to provide a good fit to some cosmic microwave background (CMB) data, while being somewhat disfavored by Planck CMB polarization data. To clarify this situation, we investigate in this paper CMB-independent constraints on this scenario from the Full Shape of the galaxy power spectrum. Although this scenario predicts significant changes to the linear matter power spectrum, we find that it can provide a good fit to the the galaxy power spectrum data. Interestingly, we show that the data display a modest preference for a delayed onset of neutrino free-streaming over the standard model of cosmology, which is driven by the galaxy power spectrum data on mildly non-linear scales. This conclusion is supported by both profile likelihood and Bayesian exploration analyses, showing robustness of the results. Compared to the standard cosmological paradigm, this scenario predicts a significant suppression of structure on subgalactic scales. While our analysis relies on the simplest cosmological representation of neutrino self-interactions, we argue that this persistent - and somehow consistent - picture in which neutrino free-streaming is delayed motivates the exploration of particle models capable of reconciling all CMB, large-scale structure, and laboratory data.Comment: 14 pages + references, 9 figures, 2 table